Placenta Cell System

Here you can find endothelial cells, epithelial cells, trophoblasts, fibroblasts and mesenchymal stromal cells. You can also find medium to grow the cells as well as RNA, DNA and protein derived from these cells.

The placenta is an orgen that connects via umbilical cord of the developing fetus to the mother’s uterine wall. Placenta uptakes nutrient, eliminates waste and permits gas exchange via the mother's blood. In humans, the placenta is average 22 cm in length and weighs approximately 500 grams and has a disc shape.

Human amniotic membrane is composed of an epithelial cell layer, a basement membrane and an avascular matrix. The amniotic epithelial cells (AEC) are formed from epiblasts on the 8th day after fertilization. A probable result of their embryonic origin, AEC lack major histocompatibility complex antigens and have been used for allotranplantation to treat patients with lysosomal diseases. They express neuronal and glial cell marks, produce basic fibroblast growth factors and hepatocyte growth factors and transform growth factor-beta.

The trophoblast begins at the outer covering of the early blastocyst and provides the route of nourishment between the maternal endometrium and the developing embryo. The trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. Human villous tryophoblasts (HVT) covering the villi of the placenta provide the surface for the exchange of oxygen and nutrient with the maternal circulation.

Multipotent mesenchymal stromal cells, also known as mesenchymal stem cells (MSC) are well-characterized population of adult stem cells. They have the potential to develop into mature cells that produce fat, cartilage, bone, tendons, and muscle. These properties in combination with their developmental plasticity have generated tremendous interest in the potential use of mesenchymal stem cells to replace damaged tissues. Depending on MSC culturing conditions, the MSC will differentiate into various cells.

Fibroblasts are mesenchymal cells which are derived from the embryonic mesoderm. Since tissue-specific mesenchymal cells are essential for normal organ development, the villous mesenchymal fibroblasts (VMF) have been used as a model system for studying the cellular mechanisms involved in regulating human placental growth. The VMF lie directly beneath the villous basement membrane and plays an important role in the regulation of trophoblast growth and function.