CCL22 was described initially as a constitutively produced, thymus-specific chemokine, implicated in the recruitment of T cells. One of the functions of CCL22 originally described was induction of migration of CCR4+ Th2 cells, but it has additionally been shown to regulate migration of Tregs. CCL22 has been implicated in a number of diseases, including allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Similarly, a presumed role for CCR4+ cells has been suggested for endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes
Aliases- C-C motif chemokine 22, Activated B and dendritic cell-derived, CC chemokine ABCD-1, µmall-inducible cytokine A22, Abcd1, Scya22
- Recombinant Mouse Macrophage-Derived Chemokine (CCL22)
Formulation- Recombinant mouse CCL22 is presented as 0.2 µm filtered PBS pH 7.5.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months.
Avoid repeated freeze/thaw cycles.