Wnt-1 is a secreted protein that signals through the frizzled family of seven transmembrane receptors. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the up-regulation of over fifty genes. Stabilization and resulting accumulation of the intracellular signaling protein β-catenin is an important aspect of Wnt-1 signaling. While known to play in role as a developmental protein, elevated levels of Wnt proteins have also been associated with tumorigenesis.
Aliases- Proto-oncogene Int-1 homolog, Wnt-1
- Recombinant Human Proto-oncogene Wnt-1 (WNT1)
Formulation- Lyophilized from a 0.2 µm filtered solution in Tris and DTT
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.