TWEAK is a TNF superfamily transmembrane protein which is expressed in many different cells and tissues, such as the heart, spleen and small intestine. Two different receptors have been identified that bind TWEAK; the Death Receptor 3 (DR3) and the TWEAK Receptor (TWEAKR). While DR3 is expressed mainly in tissues that have high concentration of lymphocytes, the mitogen-inducible TWEAKR is has been shown to be expressed in fibroblasts, hepetocellular carcinomas and endothelial cells. Recombinant human TWEAK comprises the TNF homologous (secreted region) of TWEAK.
Product Name- Recombinant Human TWEAK (TNFSF12)
Aliases- TWEAK, Tumor necrosis factor ligand superfamily member 12, TNFSF12, DR3LG, Apo3-Ligand
- Recombinant Human TNF-Related Weak Inducer of Apoptosis (TNFSF12)
Formulation- Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.