A cytotoxic protein, TRAIL initiates apoptosis in tumor cells by binding the death-signalling receptors; DR4 and DR5. In its active conformation, TRAIL forms homotrimers. TRAIL transcripts have been shown to be constitutively expressed in a variety of human tissues. There are five known TRAIL receptors: two which transduce apoptotic signals, two which function as decoys to block TRAIL-induced apoptosis and osteoptotegrin.
Product Name- Recombinant Human TRAIL (TNFSF10)
Aliases- TRAIL, Tumor necrosis factor (Ligand) family member 10, TNFSF10, Apo2 Ligand, TL2
- Recombinant Human TNF-Related Apoptosis-Inducing Ligand (TNFSF10)
Formulation- Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.