Fractalkine is a type I membrane protein that signals through the CX3CR1 receptor. The extracellular domain of Fractalkine is released by protease cleavage – producing soluble Fractalkine. Fractalkine has been found in many tissues and shown to be up-regulated in endothelial cells and microglia in response to inflammatory signals. Fractalkine is also involved in leukocyte adhesion as well as attracting monocytes, microglia cells and NK cells.
Product Name- Recombinant Human Fractalkine (CX3CL1)
Aliases- C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, µmall-inducible cytokine D1
Formulation- Lyophilized from a 0.2 µm filtered solution in 20mM phosphate buffer and 50mM NaCl, pH 7.4
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.