Human Chemerin, also known as Tazarotene induced Gene 2 (TIG2), is an adipokine that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1. Its other ligands include G protein-coupled receptor 1 and chemokine receptor-like 2. Chemerin is expressed in various tissues where its biologically active form is generated by proteolytic removal of C-terminal residues by circulating proteases. In human, the soluble protoform gets processed into a monomeric, heparin binding bioactive molecule that can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases.
Product Name- Recombinant Human Chemerin
Aliases- RAR-responsive protein TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RARRES2
Formulation- Lyophilized from a 0.2 µm filtered solution containing 0.1% TFA
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.