Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. It has a molecular weight of 5 kDa, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation.
Synonyms: Thymosin beta-4, T beta 4, Fx, TB4X, PTMB4, TMSB4.
Formulation: The protein (1mg/ml) was lyophilized with no additives.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 98% as determined by RP-HPLC.
Amino acid sequence: Thymosin b4 has an a. a. sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.
Uniprot ACC number: P62328
Transportation method: Shipped at room temperature.
Stability: Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution T beta 4 should be stored at +4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Solubility: It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
References: Title: Regenerative protein thymosin b -4 is a novel regulator of purinergic signaling. Publication: Published online before printNovember 24, 2010, doi:10.1096/fj.10-169417March 2011The FASEB Journalvol. 25no. 3907-915. Link: http://www. Fasebj.org/content/25/3/907. Full.pdf+html
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