Human Annulus Fibrosus Cells, Passage 1
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Human Annulus Fibrosus Cells, Passage 1Human Annulus Fibrosus Cells, Passage 1Human Annulus Fibrosus Cells, Passage 1

Human Annulus Fibrosus Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

Degeneration of the intervertebral disk is a major pathological process implicated in low back pain. The causes of low back pain include genetics, environmental factors, and psychosocial factors. The anulus fibrosus makes up the peripheral portion of the disk structure, and is composed of fibrocartilage and type I and II collagen. Cells of the intervertebral disc are influenced by both biophysical and mechanical factors in their local environment. The anulus fibrosus cells can be stimulated by interleukin 1 beta to produce factors implicated in local degradative and inflammatory processes. Although mechanical stress is an important modulator of degeneration, the underlying molecular mechanism remains unclear. Human annulus fibrosus cells provide an in vitro model for the study of cellular and molecular events involved in disc degeneration, tissue engineering and cell therapy for spinal disc disorders. (SC4810)
Article number:SC4810
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