Human Renal Mesangial Cells, Passage 1
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Human Renal Mesangial Cells, Passage 1Human Renal Mesangial Cells, Passage 1Human Renal Mesangial Cells, Passage 1SC4200

Human Renal Mesangial Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

Renal mesangial cells (RMC) are perivascular cells located within the central portion of the glomerular tuft between capillary loops. Mesangial cells have a variety of functions including synthesis and assembly of the mesangial matrix, endocytosis and processing of plasma macromolecules, and control of glomerular hemodynamics via mesangial cell contraction or release of vasoactive hormones. Mesangial cells also synthesize, assemble and control turnover of the mesangial matrix. Matrix overproduction of mesangial cells has been observed in various glomerular diseases, such as IgA nephropathy, mesangioproliferative glomerulonephritis, lupus nephritis, glomerulosclerosis and diabetic nephropathy. Such critical involvements suggest renal mesangial cells are an ideal model for studying mesangial injury and glomerular functions under both physiological and pathophysiological conditions. (SC4200)
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