Human Villous Trophoblasts
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Human Villous TrophoblastsHuman Villous TrophoblastsDSCN0201SC7120

Human Villous Trophoblasts

Human Primary Cells

The trophoblast begins at the outer covering of the early blastocyst and provides the route of nourishment between the maternal endometrium and the developing embryo. The trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. Human villous tryophoblasts (HVT) covering the villi of the placenta provide the surface for the exchange of oxygen and nutrients with the maternal circulation. They synthesize and release chorionic gonadotropin, placental lactogen and angiogenin and express CXCR4, CCR5 and prolactin gene family. They acquire CCR1 as they differentiate to an invasive phenotype at the villous-anchoring sites. The features of HVT, together with the recent establishment of trophoblast stem cells, make them an ideal genetic platform to study cell differentiation and organogenesis. (SC7120)
Article number:SC7120
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