Human Hair Inner Root Sheath Cells, Passage 1
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Human Hair Inner Root Sheath Cells, Passage 1Human Hair Inner Root Sheath Cells, Passage 1Human Hair Inner Root Sheath Cells, Passage 1

Human Hair Inner Root Sheath Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

The inner root sheath (IRS) of human hair follicles consists of three concentric cell layers: the cuticle, Huxley's layer, and Henle's layer. All three layers are formed from the peripheral mass of matrix cells in the hair bulb. The formation of the IRS during the evolution of the mammalian epidermis allowed the physiological exit of hairs produced inside the skin. Its dimension and curvature largely determines the shape of the hair. Previous studies have reported the expression of specific type II epithelial keratins and a unique fibroblast growth factor (FGF) in the IRS, suggesting a preferential role for these proteins in hair development. (SC2430)
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