Human Pulmonary Artery Adventitial Fibroblasts
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Human Pulmonary Artery Adventitial FibroblastsHuman Pulmonary Artery Adventitial FibroblastsHuman Pulmonary Artery Adventitial FibroblastsSC3120

Human Pulmonary Artery Adventitial Fibroblasts

Human Primary Cells

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of the easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection to microinjection. There is evidence showing that fibroblasts in various organs are intrinsically different. Specifically, pulmonary artery adventitial fibroblasts (PAAF) are important modulators of vascular wall function. During pathological conditions, such as hypoxia-induced pulmonary hypertension, HPAAF become proliferative which contributes to adventitial thickening. (SC3120)
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