Human Gallbladder Fibroblasts
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Human Gallbladder FibroblastsHuman Gallbladder FibroblastsHuman Gallbladder Fibroblasts

Human Gallbladder Fibroblasts

Human Primary Cells

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies, as they are one of the easiest types of cells to grow in culture. Their durability makes them amenable to a variety of manipulations ranging from gene transfection to microinjection. Fibroblasts secrete a nonrigid extracellular matrix that is rich in type I and/or type III collagen. They are responsible for synthesis of extracellular matrix in connective tissue and play a central role in wound healing. Human gallbladder fibroblasts (HGBF) are responsible for eicosanoid synthesis, specifically PGI2. Chronic stimulation of HGBF results in up-regulated synthesis and release of PGI2, which aids in formation of early acute cholecystitis. HGBF are very versatile cells and could be used to study many different conditions, including early stages of acute cholecystitis. (SC5430)
Article number:SC5430
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