Human Thymic Fibroblasts
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Human Thymic FibroblastsHuman Thymic FibroblastsHuman Thymic Fibroblasts

Human Thymic Fibroblasts

Human Primary Cells

Fibroblasts have been extensively used for a wide range of cellular and molecular studies as they are one of easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection to microinjection. In general, fibroblasts secrete a non-rigid extracellular matrix (ECM) which is rich in type I and/or type III collagen. There is evidence showing that fibroblasts in various organs are intrinsically different. A previous study demonstrated that thymic fibroblasts are derived from the embryonic neural crest, which first surrounds the thymus as mesenchyme and later migrates into the thymic epithelium to form a network of fibroblasts. Thymic fibroblasts and the associated ECM have been shown to be responsible for normal thymus morphogenesis and lymphopoiesis. (SC3930)
Article number:SC3930
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