Human Pancreatic Stellate Cells, Passage 1
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Human Pancreatic Stellate Cells, Passage 1Human Pancreatic Stellate Cells, Passage 1Human Pancreatic Stellate Cells, Passage 1Human Pancreatic Stellate Cells, Passage 1

Human Pancreatic Stellate Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

Pancreatic Stellate Cells (HPaSteC) are the main fibroblastic cells of the pancreas. HPaSteC are responsible for the synthesis and the degradation of the extracellular matrix proteins that promote tissue repair. They are found adjacent to pancreatic acinar cells and around small pancreatic ducts and blood vessels. When HPaSteC are activated, they assume myofibroblast-like morphology and secrete excessive amounts of extracellular matrix proteins, which can lead to desmoplasia in chronic pancreatitis and adenocarcinoma. Recent studies have shown that HPaSteC can also act as progenitor cells, immune cells, and intermediaries in exocrine pancreatic secretion. Additionally, HPaSteC stimulate pancreatic cancer proliferation, inhibit apoptosis, and enhance angiogenesis . HPaSteC are the ideal model for studying pancreatic tumor formation and they can be used to develop novel therapies for treatment of chronic pancreatitis and adenocarcinoma. (SC3830)
Article number:SC3830
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