Immortalization of the schwann cells was spontaneous.
Immortalization Method: Spontaneous
BioSafety Level: II
Organism: Mouse (M. musculus)
Species: Mouse
Source Organs: Brain
Organ Type: Brain
Growth Properties: Adherent
Morphology: Spindle-shaped
Quality Control: 1) Immunocytochemistry; 2) Western Blot; 3) Neurite outgrowth and neuronal cell survival assays; 4) ELISA; 5) LC/MS/MS; 6) Microarray analysis; 7) Real-time RT-PCR
Shipping Condition: Dry Ice
Storage Condition: liquid nitrogen or -180°C
Reference: Niimi, N., Yako, H., Takaku, S., Kato, H., Matsumoto, T., Nishito, Y., Watabe, K., Ogasawara, S., Mizukami, H., Yagihashi, S., Chung, S. K., & Sango, K. (2018). A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism. Journal of neurochemistry, 144(6), 710–722. https://doi.org/10.1111/jnc.14277