Rabbit Renal Proximal Tubular Epithelial Cells
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Rabbit Renal Proximal Tubular Epithelial CellsRabbit Renal Proximal Tubular Epithelial CellsRabbit Renal Proximal Tubular Epithelial Cells

Rabbit Renal Proximal Tubular Epithelial Cells

Rabbit Primary Cells

Renal proximal tubular epithelial cells (RPTEpiC) play a crucial role in renal function. They reabsorb nearly all the glucose and amino acids in the glomerular filtrate, while allowing substances of no nutritional value to be excreted into the urine. RPTEpiC are also a major site of injury in a variety of congenital, metabolic, and inflammatory diseases. RPTEpiC can produce inflammatory mediators, such as cytokines or chemokines, and actively participate in acute inflammatory processes by affecting and directing leukocyte chemotaxis via the production of IL-8 [1, 2]. RPTEpiC express IL-2R alpha and MHC class II antigens during inflammation, after renal transplantation, and during crescentic glomerulonephritis, suggesting that these cells have the capacity to participate in the pathogenesis of immune renal injury [3]. Rabbit RPTEpiC (RabRPTEpiC) are a useful model for studying their role in renal disease and injury. (Catalog number: SCRab4100)
Article number:SCRab4100
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