and myelinate axons of peripheral nerves . Each Schwann cell wraps around the shaft of an individual peripheral axon, forming myelin sheaths along segments of the axon. Schwann cells play important roles in the development, function, and regeneration of peripheral nerves. When an axon is dying, the Schwann cells surrounding it aid in its digestion, leaving an empty channel formed by successive Schwann cells, through which a new axon may then grow from a severed end. The number of Schwann cells in peripheral nerves is tightly regulated . Their proliferation in vitro can be stimulated by various growth factors including PDGF, FGF, neuregulin, and others . Schwann cells provide a relatively simple, well-defined, and accessible mammalian model for the study of a number of developmental questions
It is recommended to use Schwann Cell Medium (SCM, Cat. No. SC1701 ) for culturing MSC in vitro.
Mouse Schwann Cells, MSC are for research use only. They are not approved for human or animal use, or for application in in vitro diagnostic procedures.
Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments.
Cells are only warranted if ScienCell media and reagents are used and the recommended protocols are followed.
 Jessen KR, Mirsky R. (1999) “Schwann cells and their precursors emerge as major regulators of nerve development.” Trends Neurosci. 22: 402-10. Syroid DE, Maycox PR, Burrola PG, Liu N, Wen D, Lee KF, Lemke G, Kilpatrick TJ. (1996) “Cell death in the Schwann cell lineage and its regulation by neuregulin.” Proc Natl Acad Sci USA. 93: 9229-34.  Rahmatullah M, Schroering A, Rothblum K, Stahl RC, Urban B, Carey DJ. (1998) “Synergistic regulation of Schwann cells proliferation by heregulin and forskolin.” Mol Cell Biol. 18: 6245-52.