TSLP is a hemopoietic protein that was initially identified from mouse thymic stromal cell line that promoted the development of B cells. TSLP overlaps biological activities with IL-7 and can co-stimulate growth of thymocytes and mature T cells alongside supporting lymphopoiesis. Human TSLP shares approximately 43% amino acid sequence identity with mouse TSLP. Human TSLP has been detected in many tissues although the highest level of expression has been found in the heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7R-alpha and the TSLP-R.
Aliases- Thymic stromal lymphopoietin, TSLP
- Recombinant Human Thymic Stromal Lymphopoietin (TSLP)
Formulation- Human TSLP was Lyophilized from a 0.2 µm filtered concentrated (1.0 mg/mL) solution in 20 µm PB, pH 7.4, 150 µm NaCl.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.