TGFB1 is the prototype member of the TGF-beta super-family that includes Inhibins, Activin A, MIS (Müllerian inhibiting substance), BMP (bone morphogenetic proteins), dpp (decapentaplegic) and Vg-1. TGFB1 is the most potent known growth inhibitor for normal and transformed epithelial cells, endothelial cells, fibroblasts, neuronal cells, lymphoid cells and other hematopoietic cell types. TGF-beta inhibits the proliferation of T lymphocytes by down-regulating predominantly IL2 mediated proliferative signals and also inhibits the growth of natural killer cells. Recombinant human TGFB1 is a disulfide linked homodimer protein that migrates at approximately 26kDa under non-reducing conditions.
Product Name- Recombinant Human TGF Beta-1 (TGFB1)
Aliases- Transforming growth factor beta-1, TGF-beta-1, Differentiation inhibiting factor, Latency-associated peptide, LAP
Formulation- Lyophilized from 0.2 µm filtered PBS solution pH 7.4
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months.
Avoid repeated freeze/thaw cycles.