CCL18, also designated dendritic cell (DC)3-derived CC chemokine 1, pulmonary and activation-regulated chemokine, alternative macrophage activation-associated CC chemokine 1, and MIP-4, is a human chemokine structurally related to CCL3. CCL18 was shown to be expressed in germinal centers of tonsils by dendritic cells and to attract mainly naive T cells, CD38 mantle zone B lymphocytes and DC. The production of CCL18 by APC is enhanced by Th2 cytokines like IL-4 and IL-13 and suppressed by IFN-gamma.
Product Name- Recombinant Human MIP-4 (CCL18)
Aliases- MIP4, CCL18, Pulmonary and activation-regulated chemokine, PARC, DC-CK1, µmAC-1, C-C motif chemokine 18, µmall-inducible cytokine A18
- Recombinant Human Macrophage Inflammatory Protein-4 (CCL18)
Formulation- Recombinant CC18 was lyophilized from a 0.2 µm filtered 20 µm PB,100 µm NaCl solution pH 7.5.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.