CCL23 (MPIF-1, CK8, SCYA23), a member of the CC chemokine family, was originally isolated from a human aortic endothelial cell library and from the human monocytic cell line THP-1. It is most closely related to MIP-1 and interacts with its receptor CCR1, which is expressed on monocytes, dendritic cells, lymphocytes, and endothelial cells. Functionally, CCL23 has chemotactic activity for monocytes, DC, lymphocytes, neutrophils, osteoclast precursor cells, and endothelial cells. In contrast, CCL23 reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages, whereas it enhances angiogenesis of endothelial cells
Product Name- Recombinant Human MIP-3 (CCL23)
Aliases- CK-beta-8, CKB-8, MIP3, Myeloid progenitor inhibitory factor 1, MPIF-1, µmall-inducible cytokine A23, MIP3, MPIF1, SCYA23, CCL23, C-C motif chemokine 23
- Recombinant Human Macrophage Inflammatory Protein-3 (CCL23)
Formulation- Recombinant CCL23 was lyophilized from a 0.2 µm filtered 20 µm PB, 100 µm NaCl solution pH 7.5.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.