Originally identified as a gene induced by IL-9 in mouse T cells and mast cells, IL-22 is a member of the IL-10 family of cytokines. IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the pancreas and liver. The IL-22 receptor complex consists of two receptor subunits, IL-22R and IL-10R-beta that belong to the class II cytokine receptor family. Recombinant human IL-22 is a non-disulfide-linked homodimeric protein.
Aliases- IL-22, IL-TIF, Cytokine Zcyto18, IL-10-related T cell-derived-inducible factor, ILTIF, ZCYTO18
- Recombinant Human Interleukin-22 (IL22)
Formulation- Recombinant Interleukin-22 was lyophilized from 0.2 µm filtered concentrated (1.0 mg/mL) solution in 500 µm NaCl, 20 µm Tris, pH 8.0.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.