CCL15 is a human chemokine which acts predominantly on chemokine receptor CCR1 and to a lesser degree on CCR3. It is a potent chemoattractant for monocytes and lymphocytes in vitro and, after i.p. application, CCL15 induces recruitment neutrophils, monocytes, and lymphocytes into mouse peritoneum. CCL15 is constitutively expressed in the gut and in the liver and was identified to circulate in human plasma. The N-terminus of CCL15 was found to be important to exert its full biological activity. HCC-2 shares significant sequence homology with CKb8 and the murine chemokines C10, CCF18/MRP-2, and macrophage inflammatory protein 1g, which all contain six instead of four conserved cysteines.
Product Name- Recombinant Human HCC-2 (CCL15)
Aliases- Macrophage Inflammatory Protein-5, MIP-5, Chemokine CC-2, CCL15, Leukotactin-1, Lkn-1, MIP-1 delta, Mrp-2b, NCC-3, µmall-inducible cytokine A15, MIP5, NCC3, SCYA15, HCC2
Formulation- Recombinant HCC-2 was lyophilized from a 0.2 µm filtered 20 µm PB,100 µm NaCl solution pH 7.5.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.