EGFL7 is an 31 kDa secreted protein that contains an Emilin-like (EMI) domain, and two epidermal growth factor (EGF) domains - one of which binds calcium. Based on these domains, it has been hypothesized that EGFL7 may self-assemble, similar to extracellular matrix (ECM) proteins and, thus, incorporate into ECM. EGFL7 has been reported to stimulate cell adhesion as well as motility in a manner similar to ECM proteins. EGFL7 has been shown to be primarily expressed by developing ECs but also by primordial germ cells and some central nervous system neurons. Interestingly, EGFL7 expression markedly decreases in ECs in postnatal life, but can be strongly up-regulated after various tissue injuries that lead to increased angiogenic responses.
Aliases- EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, MEGF7, EGF-L7, NOTCH4-like protein, Vascular endothelial statin, VE-statin, Zneu1
- Recombinant Human Epidermal Growth Factor-Like Protein 7 (EGFL7)
Formulation- Recombinant Human EGFL7 is lyophilized from a 0.2 µm filtered solution (pH 7.0) in 100 µm glycine, 10 µm NaCl, 10% glycerol and 5% trehalose.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- This protein can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.