CCL21, which is a member of the family of CC-Chemokines, has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. CCL21 selectively stimulates the chemotaxis of adult T lymphocytes and is expressed preferentially in lymph node tissue. CCL21 is critical for adult T cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T cell trafficking through nodal tissue.
Aliases- C-C motif chemokine 21, 6Ckine, Beta-chemokine exodus-2, SLC, µmall-inducible cytokine A21, SCYA21
- Recombinant Human Secondary Lymphoid-Tissue Chemokine (CCL21)
Formulation- Recombinant CCL21 was lyophilized from a 0.2 µm filtered solution in 2.5% glycine, 0.5% sucrose, 0.01% Tween80, 5 µm Glutamic acid, pH 4.5.
Endotoxin Level- <1.0 EU/µg of recombinant protein as determined by the LAL method.
Storage Condition- The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at +2° to +8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.