Bone Marrow Mononuclear Cells (BMMC) are located in the bone marrow and have regenerative capabilities. Primary BMMC are a heterogeneous population of single nucleus cells which include hematopoietic stem cells, hematopoietic progenitor cells, immature monocytes, and immature lymphocytes [1]. Recent studies suggest that BMMC are suitable as a cell therapy to treat a variety of diseases such as cardiovascular disease, type 1 diabetes, and ischemic stroke [2, 3, 4]. BMMC may also be used for bone tissue engineering [1]. Primary mouse BMMC (MBMMC) can be utilized to further study BMMC as a potential cell therapy.
Recommended Medium
It is recommended to use HematoGro Medium (Cat. No. SC5501) for short-term maintenance of Mouse Bone Marrow Mononuclear Cells
Product Use
Mouse Bone Marrow Mononuclear Cells from C57BL/6 are for research use only. They are not approved for human or animal use, or for application in in vitro diagnostic procedures.
Storage
Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments.
Shipping
Dry ice.
Warranty
Cells are only warranted if ScienCell media and reagents are used and the recommended protocols are followed.
References
[1][1] Henrich D, Verboket R, Schaible A, Kontradowitz K, Oppermann E, Brune J, Nau C, Meier S, Bonig H, Marzi I, Seebach C. (2015) "Characterization of bone marrow mononuclear cells on biomaterials for bone tissue engineering in vitro." Biomed Res Int. 10: 1-12.
[2] Savitz S, Misra V, Kasam M, Juneja H., Cox C, Alderman S, et al. (2011). "Intravenous autologous bone marrow mononuclear cells for ischemic stroke." Ann Neurol. 70:59-69.
[3]Fotino C, Ricordi C, Lauriola V, Alejandro R, Pileggi A. (2010) "Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent diabetes." Rev Diabet Stud. 7(2): 144-157.
[4] Arnous S, Mozid A, Martin J, Mathur A. (2012) "Bone marrow mononuclear cells and acute myocardial infarction." Stem Cell Res. 3(1): 2-10.