Ready-to-use 3D Hepatocyte-Stellate Cell Spheroids
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Ready-to-use 3D Hepatocyte-Stellate Cell SpheroidsReady-to-use 3D Hepatocyte-Stellate Cell SpheroidsReady-to-use 3D Hepatocyte-Stellate Cell SpheroidsReady-to-use 3D Hepatocyte-Stellate Cell Spheroids

Ready-to-use 3D Hepatocyte-Stellate Cell Spheroids

Ready-to-use Spheroids


Catalog number: SCSP3D-5300

Unit size: 1 kit

ScienCell has developed the ready-to-use 3D liver co-culture spheroids composed of hepatocytes and hepatic stellate cells at a 2:1 ratio. In 3D culture, hepatic stellate cells not only support the formation of compact hepatocyte spheroids by matrix remodeling, but also significantly improve the liver-specific functions. For example, the mRNA expression levels of phase I and II enzymes (CYP3A4, CYP2D6, GSTT1, and ABCB11), and hepatic markers (CASR, PPARA, HNF4A, and ALB) are significantly higher in hepatocyte-stellate cell co-culture spheroids (SP3D-HSteCS) versus the 3D hepatocyte monocultures. SP3D-HSteCS, therefore, are a more integrated co-culture system designed to study the complex cellular crosstalk or can be used as a tool to prolong hepatocyte function in a defined, serum-free 3D medium.
Article number:SCSP3D-5300
Unit:pcs
Stock status:Special Order Item
4.232,00 / pcs
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SCSP3D-5300.pdf