Liver fibrogenesis and angiogenesis are closely linked processes. For example, in physiological conditions, hepatic sinusoidal endothelial cells (HSEC) maintain hepatic stellate cell (HSteC) quiescence, thereby inhibiting intrahepatic vasoconstriction and fibrosis development. When capillarized, however, hepatic sinusoidal endothelial cells lose their capacity to inactivate hepatic stellate cells, thus promoting fibrogenesis and intrahepatic vasoconstriction.