Human Tracheal Epithelial Cells, Passage 1
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Human Tracheal Epithelial Cells, Passage 1Human Tracheal Epithelial Cells, Passage 1Human Tracheal Epithelial Cells, Passage 1SC3220

Human Tracheal Epithelial Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

The respiratory epithelium is composed of a mixed population of ciliated, nonciliated, and mucous-secreting cells from proximal to distal airways. The individual characteristics of these cells create not only an effective physical barrier against various noxious substances, but also a highly sophisticated host defense system by producing and releasing a large number of chemical mediators and cytokines. The bronchial epithelium consists of the surface epithelial cells and mucus glands. The surface epithelial cells are made up of three principle cell types: basal, goblet, and ciliated cells, of which the latter two form a suprabasal columnar structure and are necessary for mucociliary clearance. Studies using bronchial epithelial cells (BEpiC) have demonstrated that IL-4 and IL-13 stimulation can modify cellular proliferation, ciliary beating, and mucous production. BEpiC proliferation is also regulated in part by EGF receptor signaling. (SC3220)
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