Human Renal Proximal Tubular Epithelial Cells, Passage 1
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Human Renal Proximal Tubular Epithelial Cells, Passage 1Human Renal Proximal Tubular Epithelial Cells, Passage 1Human Renal Proximal Tubular Epithelial Cells, Passage 1SC4100

Human Renal Proximal Tubular Epithelial Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

Renal proximal tubular epithelial cells (PTEpiC) play a crucial role in renal function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the urine. PTEpiC are located near injury sites in a variety of congenital, metabolic, and inflammatory diseases. PTEpiC can produce inflammatory mediators such as cytokines and chemokines and actively participate in acute inflammatory processes by affecting and directing leukocyte chemotaxis via the production of IL-8. PTEpiC express IL-2R alpha and MHC class II antigens during inflammation, after renal transplantation, or in crescentic glomerulonephritis. PTEpiC culture provides a useful in vitro model for studying the relationship between tubular cells and renal disease. (SC4100)
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