Human Iris Fibroblasts
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Human Iris FibroblastsHuman Iris FibroblastsHuman Iris Fibroblasts

Human Iris Fibroblasts

Human Primary Cells

The iris is a pigmented disk with a variable aperture which controls the size of the pupil and the amount of light reaching the retina. It consists of the anterior limiting layer, the stroma, the dilator muscle layer, and the posterior pigmented epithelium. Iris fibroblasts (IrF), which are located in the iris, are mesenchymal cells derived from the embryonic mesoderm. The main functions of IrF are to maintain the structural integrity of the connective tissue and to aid in tissue repair and remodeling. Under disease conditions, such as with rubeosis iridis, neovascularization can occur on the anterior surface of the iris and result in fibrosis. If the rubeosis iridis condition is left untreated, a neovascular glaucoma can develop. Patients with diabetes and diabetic retinopathy are at a higher risk of developing rubeosis iridis. Human IrF (HIrF) cultures can be used as an in vitro model for studying fibrosis and associated disorders. (6610)
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