Human Hepatic Stellate Cells, Passage 1
(Click to display a larger image)
Human Hepatic Stellate Cells, Passage 1Human Hepatic Stellate Cells, Passage 1Human Hepatic Stellate Cells, Passage 1SC5300

Human Hepatic Stellate Cells, Passage 1

Cryopreserved Primary Cells, Single Donor

Hepatic stellate cells (HSteC) are intralobular connective tissue cells presenting myofibroblastlike or lipocyte phenotypes. They participate in the homeostasis of liver extracellular matrix, repair, regeneration, fibrosis and control retinol metabolism, storage and release. Following liver injury, HSteC transform into myofibroblast-like cells and are the major source of type I collagen in the fibrotic liver. Beyond these features, HSteC have been implicated as regulators of hepatic microcirculation via cell contraction, and in disease states, in the pathogenesis of intrahepatic portal hypertension. Proliferation and migration of HSteC and expression of chemokines are involved in the pathogenesis of liver inflammation and fibrogenesis. New insight into the molecular regulation of HSteC activation will lead to therapeutic approaches in treatment of hepatic fibrosis, and could lead to reduced morbidity and mortality in patients with chronic liver injury. (SC5300)
Article number:SC5300
Unit:
Stock status:Special Order Item
2.244,00€ /
Qty:
Product Sheet
Print
Show large image
PDF
Back
Attached files

SC5300.pdf