Human Esophageal Fibroblasts
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Human Esophageal FibroblastsHuman Esophageal FibroblastsHuman Esophageal Fibroblasts

Human Esophageal Fibroblasts

Human Primary Cells

Esophageal fibroblasts, which line the lamina propria of the upper and lower esophagus, are mesenchymal cells derived from the embryonic mesoderm. Fibroblasts secrete a non-rigid extracellular matrix that is both rich in type I and/or type III collagen. They are responsible for much of the synthesis of extracellular matrix in connective tissues and play a central role in wound healing. They have been extensively used for a wide range of cellular and molecular studies, as they are one of the easiest types of cells to grow in culture. In addition, their durability makes them amenable to a variety of manipulations ranging from gene transfection to microinjection. Esophageal fibroblasts have been shown to contribute to the esophageal squamous cell carcinoma-induced angiogenesis through the TGF-β and VEGF signaling pathways. (SC2730)
Article number:SC2730
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